Understanding How Testosterone Affects Men

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The complex effects of testosterone, investigators found, depend partly on its conversion in the body to a type of estrogen. The insights will help guide the development of better ways to diagnose and treat men who don’t produce enough natural testosterone.

Testosterone is a sex hormone that plays important roles in the body. In men, it’s thought to regulate sex drive (libido), bone mass, fat distribution, muscle mass and strength, and the production of red blood cells and sperm. A small amount of circulating testosterone is converted to estradiol, a form of estrogen. As men age, they often make less testosterone, and so they produce less estradiol as well. Thus, changes often attributed to testosterone deficiency might be partly or entirely due to the accompanying decline in estradiol.

Testosterone Injections was first used as a clinical drug as early as 1937, but with little understanding of its mechanisms. The hormone is now widely prescribed to men whose bodies naturally produce low levels. But the levels at which testosterone deficiency become medically relevant still aren’t well understood. Normal testosterone production varies widely in men, so it’s difficult to know what levels have medical significance. The hormone’s mechanisms of action are also unclear.

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A team led by Dr. Joel Finkelstein at Massachusetts General Hospital investigated testosterone and estradiol levels in 400 healthy men, 20 to 50 years of age. To control hormone levels, the researchers first gave the participants testosterone therapy injections of a drug that suppressed their normal testosterone and estradiol production. The men were randomly assigned to 5 groups that received different amounts (from 0 to 10 grams) of a topical 1% testosterone gel daily for 16 weeks. Half of the participants were also given a drug to block testosterone from being converted to estradiol.

The participants were seen every 4 weeks. Blood was taken to measure hormone levels, and questionnaires were given to assess physical function, health status, vitality, and sexual function. Body fat and muscle measurements were also taken at the beginning and end of the 16 weeks. The study was funded in part by NIH’s National Institute on Aging (NIA) and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Results appeared in the September 12, 2013, issue of the New England Journal of Medicine.

The researchers found that the dose of testosterone required to produce different effects in the body varied widely. The influence of testosterone and estradiol also differed. As the testosterone gel dose was reduced, the scientists showed, reductions in lean mass, muscle size, and leg-press strength resulted from decreases in testosterone itself. In contrast, increases in body fat were due to the related declines in estradiol. Both testosterone and estradiol levels were associated with libido and erectile function.

“This study establishes testosterone levels at which various physiological functions start to become impaired, which may help provide a rationale for determining which men should be treated with testosterone supplements,” Finkelstein says. “But the biggest surprise was that some of the symptoms routinely attributed to testosterone deficiency are actually partially or almost exclusively caused by the decline in estrogens that is an inseparable result of lower testosterone levels.”

The researchers are conducting follow-up clinical trials to address the effects of testosterone replacement both on the measures in this study and others, such as bone and prostate health.

 

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— by Harrison Wein, Ph.D.

References: Gonadal steroids and body composition, strength, and sexual function in men. N Engl J Med. 2013 Sep 12;369(11):1011-22. doi: 10.1056/NEJMoa1206168. PMID: 24024838.

Funding: NIH’s National Institute on Aging (NIA), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and National Center for Research Resources (NCRR) as well as Abbott Laboratories.

5 Comments Add yours

  1. joseph2644 says:

    Testosterone Injections Therapy, Everyone wants and expects immediate results, but the truth is, that is not a reality. It takes several months to see the full benefits of testosterone injections therapy. Testosterone replacement therapy can significantly accelerate the results of muscle, bone, and cellular reproduction. However, it is still imperative for patients to understand that slow and steady is the way to go! The same as dieting, when you lose the weight too quickly and you end up gaining it all back, leaving you right back where you started, the same is true with physical transformation and development. Exaggerated dosages of testosterone, anabolics, and/or improperly protocol led therapies may yield visibly quicker results. However, the internal damage and the level of taxing your organs have to endure, which goes hand-in-hand with that type of accelerated development, is not worth the damage was done to your physiology and endocrine system. Not to mention, and more importantly, the results obtained are the production of water-filled cells. Though the muscle may “be” bigger in size, it is not stronger than a muscle of the same size that was properly cultivated and strengthened to that size.

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  2. joseph2644 says:

    Coconut ordinary water is rich in a calcium supplement, manganese, and zinc, all of which help to keep your bones healthy and active. Consumption of coconut water may be of immense benefits since it will help improve thermal function. In the study, its observed that the level of prolactin decreased. … As prolactin levels drop, the levels of testosterone, increases, without testosterone injections also using coconut also helps with erectile dysfunction is at the top of the list of natural erectile dysfunction treatment options.

    Curious about other natural ways to treat erectile dysfunction? Sleep better. Men produce testosterone during the night so insufficient sleep can reduce testosterone levels. Another component of coconut juice is potassium which is known to help dissolve renal stones in the urine, which helps to stop the build-up of calcium supplement oxalate stone(s).

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  3. joseph2644 says:

    Blueberry smoothies are delicious, but this particular recipe for increasing testosterone and raising libido is far more than just something pleasant smoothie.

    The ingredients in this smoothie recipe play an influential part in increasing one of the most important of hormones, “Testosterone” for both men and women — testosterone.

    Testosterone Injections is the most common treatment for men going through andropause. This therapy may provide help and relief from the symptoms and help improve the quality of life in many cases, also lifestyle changes such as increased exercise, stress reduction, and proper nutrition also help.

    Testosterone Injections is the most common treatment for men going through andropause. This therapy may provide help and relief from the symptoms and help improve the quality of life in many cases, also lifestyle changes such as increased exercise, stress reduction, and proper nutrition also help.

    Testosterone therapy is available in different forms, ask your doctor he will help determine which treatment is best for you.

    TESTOSTERONE INJECTIONS: This treatment involves doses of bioidentical (Testosterone Cypionate, Testosterone Enanthate, and Testosterone Propionate).

    TESTOSTERONE PATCHES: People who wear a piece containing testosterone receive the hormone through the skin. The patches allow a slow, steady release of testosterone into the bloodstream.

    TESTOSTERONE GEL: This treatment is also applied directly to the skin, usually on the arms. Because the gel may transfer to other individuals through skin contact, a person must take care to wash the gel from the hands after each application.

    TESTOSTERONE CAPSULES: This is yet another option for testosterone replacement. Men with liver disease, poor liver function, severe heart or kidney disease, or too much calcium in their blood should avoid testosterone capsules.

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  4. joseph2644 says:

     

    Testosterone is What Exactly? … A Simple Explanation.

    Testosterone is What Exactly? Testosterone is a hormone. It is mostly instrumental in sexual reproduction and development in men. The National Institute of Health respects testosterone injections as the most important male hormone.

    Testosterone is

     

    An androgen is any natural or synthetic compound, usually a steroid hormone, which stimulates or controls the development and maintenance of male characteristics. Testosterone, Testosterone is What Exactly in its natural or synthetic state, belongs to this class of male hormones.

    Liked by 1 person

  5. joseph2644 says:

    Malted Milkshake. This recipe has one of those secreted ingredients. It’s an absolute requirement to make this recipe, so don’t even bother if you don’t have it. If you’re new to maca, grab some off Amazon and give it a go, it’s one of my favorite ingredients to add to Malted Shake.

    Liked by 1 person

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